AB0458 SURVIVAL OF SCLERODERMA PATIENTS WITH INTERSTITIAL LUNG DISEASE: OBSERVATION DATA FROM A MALAYSIAN TERTIARY CENTRE

Background: Interstitial lung disease (ILD) is the leading cause of death in scleroderma (SSc) with decline FVC as a predictor mortality patients SSc-ILD, especially early course disease. Objectives: The aim this study to determine survival rate SSc-ILD Malaysian cohort from University Malaya Medical Centre (UMMC). Methods: 61 clinically diagnosed were identified and prospectively recruited. Baseline demographic data collected. Kaplan-Meier analysis was used estimate survival. Results: Females predominant (56, 91.8%). 39 (64%) had limited cutaneous SSc. Majority ethnicity Chinese 30 (49.2%), followed by Malays 20 (32.8%), Indians 7 (11.4%) others 4 (6.6%). Mean age 56.25 (SD ± 12.5) years while mean duration (non-Raynaud’s onset) 10.5 9.2) (range 1 year 44 years) years. 29 (47.5%) positive for anti-ScL-70, whereas 6 (9.8%) anti-centromere positive. There 16 (26.2%) deaths. Median 24 Patients sharper drop probability first 10 compared next (Figure 1). subset diffuse 11 appeared have higher chance surviving above, those 2). Conclusion: results demonstrate poor patients. tends be worse SSc duration. Survival poorer subset. References: [1]Parelas A et al. Lancet Resp Med 2020 [2]Goh NS Am J Respir Crit Care 2008 Disclosure Interests: JASMIN RAJA Speakers bureau: For Boehringer Ingelheim topic on Scleroderma-ILD, Grant/research support from: From research, Shantini Muthusamy: None declared., CHOUNG MIN NG: declared.